(16d)                              -CH=CH-(2-furyl)
                                                  (16e)                              -CH=CH-CH=CH2
                                                  (16f)                                 -O-C6H5
 
Benzothiazole with cyclooxygenase (COX-1&2) inhibitor activity:
Paramashivappa et al (2003)25 have synthesized a series of 2-[[2-alkoxy- 6-pentadecylphenyl) methyl]thio]-1H-benzimidazoles/benzothiazoles and benzoxazoles and investigated their ability to inhibit human Cyclooxygenase-2-enzyme (COX-2). Compound (17) was found to be 470-fold selective towards COX-2 compared to COX-1.
 
(17)
Benzothiazole with H1- & H3- antagonist activity:
New 2-(1-Piperazinyl)- and 2-(hexahydro-1H-1
2-[1-(4-methyl and 4-ethyl)piperazinyl] analogues (18a and 18b) show increasing
4-diazepin-1-yl) benzothiazoles were organized and hardened as H1- and H3-receptor antagonists via Walczynski et al (1999).26 The undemanding alkyl substituted

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